College of Chemistry and Chemical Engineering, Liaocheng University , Liaocheng, Shandong 252059, China.
J Org Chem. 2016 Sep 2;81(17):7644-53. doi: 10.1021/acs.joc.6b01371. Epub 2016 Aug 10.
Functionalized P,C-stereogenic tertiary phosphine oxides were prepared by the addition of (RP)-menthyl phenylphosphine oxide to activated olefins, in high drP and drC, and were isolated in excellent yields. The reaction was readily catalyzed by Ca(OH)2 or occurred with gentle heating. A wide range of substrates, including vinyl ketones, esters, nitriles, and nitro alkenes, can be used in the reaction.
功能化的 P,C-手性叔膦氧化物可通过（R）-薄荷基苯膦氧化物与活性烯烃加成制备，具有高 drP 和 drC，并且以优异的产率分离。该反应可由 Ca(OH)2 容易催化，或在温和加热下进行。反应中可使用包括乙烯基酮、酯、腈和硝基烯烃在内的广泛的底物。
