Sijtsma S R, West C E, Rombout J H, Van der Zijpp A J
Department of Human Nutrition, Wageningen Agricultural University, The Netherlands.
J Nutr. 1989 Jun;119(6):940-7. doi: 10.1093/jn/119.6.940.
The effect of Newcastle disease virus (NDV, La Sota strain) infection on vitamin A metabolism was investigated in chickens maintained on normal or marginal vitamin A intake. NDV, a virus of the Paramyxoviridae family that primarily affects epithelial tissue, was administered at 4 wk of age. Plasma levels of retinol, retinol-binding protein and, to a lesser extent, transthyretin were found to be significantly lower during both the acute and postacute phases of infection in chickens fed a diet marginally deficient in vitamin A compared to noninfected birds fed the same diet, while vitamin A content in liver was unaffected. However, in chickens fed adequate vitamin A, NDV infection did not influence the parameters measured. Levels of retinol-binding protein in liver were significantly increased by inadequate vitamin A nutriture, but infection partly reduced this increase. The results suggest that the reduced vitamin A status in marginally vitamin A-deficient chickens infected with NDV can be attributed to a combination of a direct effect of the virus on retinol-binding protein metabolism in liver and an increased rate of utilization and catabolism of retinol and retinol-binding protein by extrahepatic tissues.
在摄入正常或边缘性维生素A的鸡中，研究了新城疫病毒（NDV，La Sota株）感染对维生素A代谢的影响。NDV是一种副粘病毒科病毒，主要影响上皮组织，在4周龄时给予鸡。与喂食相同日粮的未感染鸡相比，在急性和急性后期感染期间，喂食维生素A略微不足日粮的鸡血浆视黄醇、视黄醇结合蛋白以及在较小程度上的甲状腺素转运蛋白水平显著降低，而肝脏中的维生素A含量未受影响。然而，在喂食充足维生素A的鸡中，NDV感染并未影响所测参数。维生素A营养不足会使肝脏中视黄醇结合蛋白水平显著升高，但感染部分降低了这种升高。结果表明，感染NDV的边缘性维生素A缺乏鸡的维生素A状态降低，可归因于病毒对肝脏中视黄醇结合蛋白代谢的直接作用，以及肝外组织对视黄醇和视黄醇结合蛋白利用和分解代谢速率的增加。
