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髋部骨折患者的人工关节感染。与择期假体感染的差异

[Prosthetic joint infection in patients with hip fracture. Differences from infection of elective prosthesis].

作者信息

Barbero J M, Montero E, Vallés A, Plasencia M A, Romanyk J, Gómez J

机构信息

José Mª Barbero Allende, Hospital Príncipe de Asturias. Alcalá de Henares (España). Servicio de Medicina Interna. c/ Fray Luis de León 5A, 3ºC, 28012, Madrid, Spain.

出版信息

Rev Esp Quimioter. 2016 Oct;29(5):273-7. Epub 2016 Jul 28.

Abstract

OBJECTIVE

Most publications about prosthetic joint infections (PJI) are referred to elective prosthesis and they exclude arthroplasties due to hip fracture.

METHODS

We conducted a descriptive study about prosthetic joint infections after joint fracture in Alcalá de Henares Hospital (Madrid) between 2009 and 2014 and we compared with elective prosthetic infections in the same period.

RESULTS

There were 30 PJI after hip fracture and 14 elective PJI. The incidence of infection was 4.7% in arthroplasties due to hip fracture from 1.3% in elective prosthesis (RR 3.8, p=0.005). The PJI after fracture affected older patients (82.5 years vs 71.5, p=0.006), with greater comorbidity (5.4 vs 3.6, p=0.003), higher anesthetic risk (ASA>2 70% vs 21.4%, p=0.004) and higher incidence of dementia (50% vs 0%, p=0.02). Staphylococcus aureus was the most common causative agent in both groups, but there was higher incidence of Gram negative-cases in PJI after fracture group (43.3% vs 21.4%, p no significance) and cefazolin-resistance (63.3% vs 28.6%, p=0.03). In logistic regression analysis the treatment had less chance of success in PJI after fracture than elective PJI (33.3% vs 78.6%, OR 0.09, p=0.06).

CONCLUSIONS

The PJI after fracture are more frequent than elective PJI, affect older patients, with poor general condition, are produced by more resistant bacteria and have worst evolution than EPJI.

摘要

目的

大多数关于人工关节感染(PJI)的出版物都涉及择期假体,且排除了因髋部骨折进行的关节成形术。

方法

我们对2009年至2014年期间马德里阿尔卡拉德埃纳雷斯医院关节骨折后发生的人工关节感染进行了描述性研究,并与同期的择期人工关节感染进行了比较。

结果

髋部骨折后发生30例PJI,择期PJI为14例。髋部骨折关节成形术中感染发生率为4.7%,择期假体为1.3%(相对危险度3.8,p = 0.005)。骨折后PJI影响年龄较大的患者(82.5岁对71.5岁,p = 0.006),合并症更多(5.4对3.6,p = 0.003),麻醉风险更高(ASA>2 70%对21.4%,p = 0.004),痴呆发生率更高(50%对0%,p = 0.02)。金黄色葡萄球菌是两组中最常见的病原体,但骨折后PJI组革兰阴性菌病例发生率更高(43.3%对21.4%,p无显著性差异),对头孢唑林耐药率更高(63.3%对28.6%,p = 0.03)。在逻辑回归分析中,骨折后PJI的治疗成功率低于择期PJI(33.3%对78.6%,比值比0.09,p = 0.06)。

结论

骨折后PJI比择期PJI更常见,影响年龄较大、一般状况较差的患者,由耐药性更强的细菌引起,且预后比择期人工关节感染更差。

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