Wu Li-An, Kuo Wen-Hung, Chen Chin-Yu, Tsai Yuh-Show, Wang Jane
Department of Medical Imaging, Taipei City Hospital, Heping Branch, 33, Sec 2, Zhonghua Road, Zhongzheng Dist, Taipei 100, Taiwan.
Department of Medical Imaging, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei 100, Taiwan.
BMC Cancer. 2016 Jul 27;16:541. doi: 10.1186/s12885-016-2602-9.
To evaluate whether infrared (IR) imaging findings are associated with prognosis in patients with invasive breast carcinomas.
This study was approved by the institutional review board of the research ethics committee of our hospital, and all participants gave written informed consent. From March 2005 to June 2007, we enrolled 143 patients with invasive breast cancer that underwent preoperative IR imaging. We used five IR signs to interpret breast IR imaging. Cox proportional hazards model was used to evaluate the effect of IR signs on long-term mortality.
During a median follow-up of 2451 days (6.7 years), 31 patients died. Based on the Cox Proportional Hazards Model, IR1 sign (the temperature of cancer site minus that of the contralateral mirror imaging site) was positively associated with mortality in the univariate analysis (overall mortality hazard ratio [HR], 2.29; p = 0.03; disease-specific mortality HR, 2.57; p = 0.04) as well as the multivariate analysis after controlling for clinicopathological factors (overall mortality HR, 3.85; p = 0.01; disease-specific mortality HR, 3.91, p = 0.02). In patients with clinical stage I and II disease, IR1 was also positively associated with mortality (overall mortality HR, 3.76; p = 0.03; disease-specific mortality HR, 4.59; p = 0.03). Among patients with node-negative disease, IR1 and IR5 (asymmetrical thermographic pattern) were associated with mortality (p = 0.04 for both IR1 and IR5, chi-squared test).
Breast IR findings are associated with mortality in patients with invasive breast carcinomas. The association remained in patients with node-negative disease.
NCT00166998 .
评估红外（IR）成像结果是否与浸润性乳腺癌患者的预后相关。
本研究经我院研究伦理委员会机构审查委员会批准，所有参与者均签署了书面知情同意书。2005年3月至2007年6月，我们纳入了143例行术前IR成像的浸润性乳腺癌患者。我们使用五个IR征象来解读乳腺IR成像。采用Cox比例风险模型评估IR征象对长期死亡率的影响。
在中位随访2451天（6.7年）期间，31例患者死亡。基于Cox比例风险模型，IR1征象（癌灶温度减去对侧镜像部位温度）在单因素分析中与死亡率呈正相关（总死亡率风险比[HR]，2.29；p = 0.03；疾病特异性死亡率HR，2.57；p = 0.04），在控制临床病理因素后的多因素分析中也是如此（总死亡率HR，3.85；p = 0.01；疾病特异性死亡率HR，3.91，p = 0.02）。在临床I期和II期疾病患者中，IR1也与死亡率呈正相关（总死亡率HR，3.76；p = 0.03；疾病特异性死亡率HR，4.59；p = 0.03）。在无淋巴结转移疾病患者中，IR1和IR5（不对称热成像模式）与死亡率相关（IR1和IR5的p值均为0.04，卡方检验）。
乳腺IR成像结果与浸润性乳腺癌患者的死亡率相关。这种关联在无淋巴结转移疾病患者中依然存在。
NCT00166998 。
