Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt; Solid dosage forms Department, EIPICO, Egypt.
Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
Int J Biol Macromol. 2016 Nov;92:708-714. doi: 10.1016/j.ijbiomac.2016.07.076. Epub 2016 Jul 25.
In the current study, a series of polylactic acid and polylactic-co-glycolic acid were prepared in an easy, simple, safe and economically feasible way with yield% greater than 90%. Studying the effect of a catalyst on polymerization process was performed. Riboflavin (RF) was chosen as a model drug and microencapsulated in different (drug: polymer) ratios to modify its performance via o/w emulsion solvent evaporation technique and characterized in terms of the morphology and entrapment efficiency (E.E.) and evaluated via in vitro RF release studies. It has been found that, the release rate consists a burst release at the first 12h, followed by a gradual release over 3days. The cumulative riboflavin release from these microcapsules formulations at the end of 3days was 70% and 80% for PDLA and PDLAGA respectively. The kinetics of release profiles were zero order. The highest (E.E.) of RF obtained among all formulations was 85%.
在本研究中，通过一种简单、安全且经济可行的方法，以大于 90%的产率制备了一系列聚乳酸和聚乳酸-共-羟基乙酸。研究了催化剂对聚合过程的影响。选择核黄素 (RF) 作为模型药物，并以不同的 (药物:聚合物) 比例微囊化，通过 o/w 乳液溶剂蒸发技术对其性能进行修饰，并根据形态、包封效率 (E.E.) 进行表征，通过体外 RF 释放研究进行评价。结果发现，释放速率在最初的 12 小时内有一个突释，随后在 3 天内逐渐释放。在第 3 天结束时，这些微囊制剂中累积的核黄素释放量分别为 PDLA 组的 70%和 PDLAGA 组的 80%。释放曲线的动力学为零级。所有制剂中 RF 的最高包封效率 (E.E.) 为 85%。
