Keio University, Department of Electronics and Electrical Engineering, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, JapanbKeio University, School of Integrated Design Engineering, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Keio University, School of Integrated Design Engineering, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
J Biomed Opt. 2016 Aug 1;21(8):85003. doi: 10.1117/1.JBO.21.8.085003.
The controlled release of encapsulated molecules from a microcapsule is a promising method of targeted drug delivery. Laser-triggered methods for the release of encapsulated molecules have the advantage of spatial and temporal controllability. In this study, we demonstrated the release of encapsulated molecules from biodegradable polymer-based microcapsules using near-infrared femtosecond laser pulses. The polylactic-co-glycolic acid microcapsules encapsulating fluorescein isothiocyanate-dextran molecules were fabricated using a dual-coaxial nozzle system. Irradiation of femtosecond laser pulses enhanced the release of the molecules from the microcapsules, which was accompanied by a decrease in the residual ratio of the microcapsules. The laser-induced modification of the surface of the shell of the microcapsules indicated the potential for sustained release as well as burst release.
从微胶囊中控制释放被包裹的分子是一种很有前途的靶向药物输送方法。激光触发的被包裹分子释放方法具有空间和时间可控性的优点。在这项研究中，我们使用近红外飞秒激光脉冲演示了从基于可生物降解聚合物的微胶囊中释放被包裹的分子。使用双同轴喷嘴系统制备了包封荧光素异硫氰酸酯-葡聚糖分子的聚乳酸-共-羟基乙酸微胶囊。飞秒激光脉冲的辐照增强了分子从微胶囊中的释放，同时微胶囊的残余率降低。微胶囊壳表面的激光诱导修饰表明具有持续释放和爆发释放的潜力。
Zotero 插件