Locht H, Lindström F D
Department of Medicine, University Hospital, Linköping, Sweden.
J Rheumatol. 1989 Apr;16(4):544-6.
We report a patient with Wegener's granulomatosis who was initially stabilized, but later relapsed with multiorgan involvement while taking high oral doses of cyclophosphamide (3.7 mg/kg body weight/day) and prednisolone. Remission was achieved with a combined therapy consisting of intermittent intravenous boluses of cyclophosphamide, oral prednisolone, plasmapheresis and oral trimethoprim-sulfamethoxazole. Discussion includes evaluation of the relative beneficial effect of the four treatment constituents.
我们报告了一名患有韦格纳肉芽肿的患者，该患者最初病情稳定，但后来在口服高剂量环磷酰胺（3.7毫克/千克体重/天）和泼尼松龙的情况下复发并出现多器官受累。通过环磷酰胺间歇静脉推注、口服泼尼松龙、血浆置换和口服甲氧苄啶-磺胺甲恶唑组成的联合疗法实现了缓解。讨论内容包括对四种治疗成分相对有益效果的评估。
