FOXP3在人类癌症中的作用。
The Role of FOXP3 in Human Cancers.
作者信息
Szylberg Łukasz, Karbownik Dominika, Marszałek Andrzej
机构信息
Department of Clinical Pathomorphology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland
Department of Clinical Pathomorphology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Torun, Poland.
出版信息
Anticancer Res. 2016 Aug;36(8):3789-94.
FOXP3 transcription factor can be observed as the main component of the immune system expressed in regulatory T (Treg) cells that regulate hemostasis and self-tolerance. Moreover, the altered expression of FOXP3 was found in autoimmune diseases, benign tumors and carcinomas. Latest reports indicate that the FOXP3 gene mutation can contribute to carcinogenesis, which can be associated with immune response abnormalities. Infiltration of the Treg cells into tumor cells can be associated with prognosis. Understanding the biology of the FOXP3 gene may be crucial in developing new immunotherapeutics.
FOXP3转录因子可被视为免疫系统的主要组成部分，在调节止血和自身耐受的调节性T（Treg）细胞中表达。此外，在自身免疫性疾病、良性肿瘤和癌中发现了FOXP3表达的改变。最新报告表明，FOXP3基因突变可能促成肿瘤发生，这可能与免疫反应异常有关。Treg细胞浸润肿瘤细胞可能与预后相关。了解FOXP3基因的生物学特性对于开发新的免疫疗法可能至关重要。
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