a Department of Medical Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences , Islamic Azad University , Tehran , Iran.
b Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences , Islamic Azad University , Tehran , Iran.
Hum Vaccin Immunother. 2019;15(3):620-624. doi: 10.1080/21645515.2018.1545625. Epub 2019 Jan 30.
Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment. The main members of suppressive milieu of tumor are heteroogenous groups of immune cells in which regulatory T cell is a substantial component. Tregs express different immunomodulatory molecules such as FoxP3. Transcription factor, FoxP3, is a specific intracellular marker of Treg and crucial for Treg development. Therefore it is an attractive target for cancer treatment. This article reviews some recent anti-Treg vaccine focusing on FoxP3 to ameliorate anti-tumor immune responses. Among them, fusion vaccine of FoxP3-Fc(IgG) recombinant DNA vaccine and its accordant protein vaccine represents effective results.
抗肿瘤疫苗对肿瘤细胞的免疫反应并不完美；这与肿瘤微环境中存在抑制性障碍有关。肿瘤抑制环境的主要成员是免疫细胞的异质性群体，其中调节性 T 细胞是一个重要组成部分。Tregs 表达不同的免疫调节分子，如 FoxP3。转录因子 FoxP3 是 Treg 的特异性细胞内标志物，对 Treg 的发育至关重要。因此，它是癌症治疗的一个有吸引力的靶点。本文综述了一些最近的抗 Treg 疫苗，重点是 FoxP3，以改善抗肿瘤免疫反应。其中，FoxP3-Fc（IgG）重组 DNA 疫苗及其相应的蛋白疫苗融合疫苗代表了有效的结果。
