成年Min/+小鼠早期高脂饮食暴露所致肥胖与肠道肿瘤发生不会跨代遗传。
Obesity and Intestinal Tumorigenesis in Adult Min/+ Mice from Early-life High-fat Diet Exposure Were Not Inherited Transgenerationally.
作者信息
Steffensen Inger-Lise
机构信息
Department of Toxicology and Risk Assessment, Domain for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway
出版信息
Anticancer Res. 2016 Aug;36(8):3871-82.
BACKGROUND/AIM: Exposure to 45% fat diet in utero and during nursing increased body weight and small intestinal tumor numbers in adult F1 multiple intestinal neoplasia (Min/+) mice, implicating that early-life obesogenic conditions predispose for obesity and intestinal tumorigenesis later in life. In this study, it was examined whether these effects were transferred to the next two generations.
RESULTS
In F2 mice, exposed to the obesogenic diet as germ cells within the embryonic F1 mice, there were no consistent differences in body weight, blood glucose levels or small intestinal tumor numbers whether their mother or father, both, or no parents were exposed to 45% vs. 10% fat diet. In F3 mice, never exposed to obesogenic diet, no differences were found in any end-points, whether both grandparents were exposed to 45% or 10% fat, or not.
CONCLUSION
The effects of early-life high-fat diet on adult obesity and intestinal tumorigenesis were not inherited transgenera-tionally.
背景/目的：在子宫内及哺乳期接触45%脂肪饮食会增加成年F1多发性肠道肿瘤（Min/+）小鼠的体重和小肠肿瘤数量，这表明生命早期的致肥胖环境易导致后期肥胖和肠道肿瘤发生。在本研究中，检测了这些影响是否会传递给接下来的两代。
结果
在F2小鼠中，作为胚胎期F1小鼠的生殖细胞接触致肥胖饮食，无论其母亲或父亲、父母双方或父母均未接触45%与10%脂肪饮食，其体重、血糖水平或小肠肿瘤数量均无一致差异。在从未接触致肥胖饮食的F3小鼠中，无论祖父母双方接触45%还是10%脂肪饮食，在任何终点指标上均未发现差异。
结论
生命早期高脂饮食对成年肥胖和肠道肿瘤发生的影响不会跨代遗传。
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