Muallem Mustafa Zelal, Sehouli Jalid, Almuheimid Jumana, Richter Rolf, Joukhadar Ralf, Plett Helmut
Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany
Department of Gynecology, Campus Virchow-Klinikum, Charité Medical University, Berlin, Germany.
Anticancer Res. 2016 Aug;36(8):4219-25.
BACKGROUND/AIM: We aimed to identify the surgical-pathological risk factors separately for pelvic and para-aortic lymph nodes (LN) metastases in endometrial cancer (EC).
The study cohort consisted of 179 patients with first diagnosis of EC, who were operated in our Institution between 2007 and 2014.
Pelvic and para-aortic LN dissection was performed in 115 patients (64.2%). The positive pelvic and para-aortic LN were diagnosed in 11.3% and 16.1% of cases, respectively. Patients with bad differentiated tumors (G3) showed about 5-times more risk to have affected LN. Deep infiltration of myometrium elevated the risk of pelvic LN infiltration 5 times and of para-aortic LN infiltration 14 times. G3, myometrial infiltration >50% and type II endometrial cancer correlated with a worse progression free survival (PFS) and overall survival (OS).
Tumor grade and deep myometrial invasion were the only significant predictors of pelvic and para-aortic lymph node metastases.
背景/目的：我们旨在分别确定子宫内膜癌（EC）盆腔和腹主动脉旁淋巴结（LN）转移的手术病理危险因素。
研究队列包括179例首次诊断为EC的患者，这些患者于2007年至2014年在我们机构接受手术。
115例患者（64.2%）进行了盆腔和腹主动脉旁淋巴结清扫。盆腔和腹主动脉旁淋巴结阳性分别在11.3%和16.1%的病例中被诊断出来。低分化肿瘤（G3）患者发生淋巴结受累的风险高出约5倍。肌层深度浸润使盆腔淋巴结浸润风险增加5倍，腹主动脉旁淋巴结浸润风险增加14倍。G3、肌层浸润>50%和II型子宫内膜癌与无进展生存期（PFS）和总生存期（OS）较差相关。
肿瘤分级和肌层深度浸润是盆腔和腹主动脉旁淋巴结转移的唯一重要预测因素。
