Immunochemotherapy for murine bladder tumor with a new human recombinant tumor necrosis factor (rTNF-S), VP-16 and hyperthermia.

Effects of a new recombinant human tumor necrosis factor (rTNF-S) on the growth of murine bladder tumor (MBT-2) were studied. The growth of MBT-2 was significantly inhibited by intratumor injection of rTNF-S. Moreover etoposide (VP-16) and hyperthermia at relatively low temperature enhanced the antitumor effect of rTNF-S. Since TNF is considered to have species preference, these observations may be relevant to treatments for human bladder tumor with human TNF.