ε-氨基己酸对亚洲象（印度象）血浆纤维蛋白溶解的影响。

EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS).

作者信息

Kaye Sarrah, Abou-Madi Noha, Fletcher Daniel J

出版信息

J Zoo Wildl Med. 2016 Jun;47(2):397-404. doi: 10.1638/2015-0255.1.

DOI:10.1638/2015-0255.1

Abstract

ε-Aminocaproic acid (EACA) is a lysine analogue antifibrinolytic drug used to treat bleeding disorders in humans and domestic animals. Use in zoological medicine is rare and dose recommendations are anecdotal, but EACA may be a valuable therapeutic option for bleeding disorders in exotic species, including Asian elephants ( Elephas maximus ). This study used an in vitro model of hyperfibrinolysis and a thromboelastograph-based assay to estimate the therapeutic plasma concentration of EACA in Asian elephants (61.5 μg/ml, 95% CI = 34.6-88.5 μg/ml). Substantial but incomplete inhibition of lysis was seen at relatively low concentrations of EACA (40 μg/ml). Asian elephants appear sensitive to EACA-mediated inhibition of hyperfibrinolysis. Doses published for domestic animals, targeting higher plasma concentrations, may be inappropriate in this species.

摘要

ε-氨基己酸（EACA）是一种赖氨酸类似物抗纤维蛋白溶解药物，用于治疗人类和家畜的出血性疾病。在动物园医学中的应用很少，剂量建议也只是基于经验，但EACA可能是治疗外来物种（包括亚洲象（Elephas maximus））出血性疾病的一种有价值的治疗选择。本研究使用了一种体外高纤维蛋白溶解模型和基于血栓弹力图的检测方法来估计亚洲象中EACA的治疗性血浆浓度（61.5μg/ml，95%置信区间=34.6-88.5μg/ml）。在相对较低的EACA浓度（40μg/ml）下观察到了对溶解的显著但不完全抑制。亚洲象似乎对EACA介导的高纤维蛋白溶解抑制敏感。针对更高血浆浓度的家畜公布剂量可能不适用于该物种。