Greunz Eva Maria, Simon Marie, Lemberger Karin, Galateanu Gabriela, Hermes Robert, Leclerc Antoine
J Zoo Wildl Med. 2016 Jun;47(2):645-9. doi: 10.1638/2016-0001.1.
The current report describes the temporary regression, due to intensive symptomatic treatment, of ulcerative skin lesions caused by squamous cell carcinoma in a white rhinoceros. A captive, 40-yr-old southern white rhinoceros (Ceratotherium simum simum) developed profound, ulcerative skin lesions on the pads of both hind feet. At the peak of the disease, at least one quarter of the pads was affected. A diagnosis of squamous cell carcinoma was made via biopsy. Treatment included anti-inflammatory drugs, antibiotics, and local care. The lesions regressed on both feet until they seemed clinically healed. It was presumed that long-term, anti-inflammatory treatment and local bandaging had induced the temporary regression of the lesions. Two years later, however, a small ulcerative lesion reappeared on one pad and post mortem examination confirmed that the carcinoma was also histologically present in the clinically intact tissue. No metastasis was found and computed tomography showed normal digital bones.
本报告描述了一头白犀牛因鳞状细胞癌引起的溃疡性皮肤病变，经强化对症治疗后出现暂时消退的情况。一头圈养的40岁南方白犀牛（Ceratotherium simum simum）后足掌出现了严重的溃疡性皮肤病变。在疾病高峰期，至少四分之一的脚掌受到影响。通过活检确诊为鳞状细胞癌。治疗包括使用抗炎药物、抗生素和局部护理。双脚的病变逐渐消退，直至临床症状似乎痊愈。据推测，长期的抗炎治疗和局部包扎导致了病变的暂时消退。然而，两年后，一个小的溃疡性病变在一个脚掌再次出现，尸检证实临床上看似完好的组织在组织学上也存在癌细胞。未发现转移，计算机断层扫描显示指骨正常。
