一只普通河马（河马属两栖河马）的系统性组织细胞肉瘤

SYSTEMIC HISTIOCYTIC SARCOMA IN A COMMON HIPPOPOTAMUS (HIPPOPOTAMUS AMPHIBIUS).

作者信息

da Costa Luciana Fachini, Malta Marcelo Campos Cordeiro, Tinoco Herlandes Penha, de Medeiros Lilian Botelho, Bittar Ana Luiza Sarkis Vieira, Hoffmann Aline Rodrigues, Pierezan Felipe, da Paixão Tatiane Alves, Santos Renato Lima

出版信息

J Zoo Wildl Med. 2016 Jun;47(2):650-3. doi: 10.1638/2015-0271.1.

DOI:10.1638/2015-0271.1

PMID:27468044

Abstract

A 37-yr-old captive common hippopotamus (Hippopotamus amphibius) developed lethargy and decline in mobility that progressed to death, despite supportive therapy. Histopathologic examination revealed severe, diffuse, intravascular and interstitial infiltration of neoplastic histiocytes in the spleen, liver, lymph nodes, lungs, large intestine, kidneys, and thyroid gland. Neoplastic cells were pleomorphic with marked anisocytosis and anisokaryosis, scattered multinucleated giant cells, numerous bizarre mitotic figures, and marked erythrophagocytosis. Immunohistochemistry demonstrated that neoplastic cells were positive for ionized calcium-binding adapter molecule 1 (a histiocytic marker) and negative for CD3 (a T-cell marker) and myeloperoxidase, confirming the diagnosis of systemic histiocytic sarcoma.

摘要

一只37岁的圈养普通河马（河马属两栖河马）出现嗜睡和活动能力下降，尽管进行了支持性治疗，但病情仍不断发展直至死亡。组织病理学检查显示，脾脏、肝脏、淋巴结、肺、大肠、肾脏和甲状腺中存在严重的、弥漫性的肿瘤性组织细胞血管内和间质浸润。肿瘤细胞多形性明显，有显著的细胞大小不等和核大小不等，散在的多核巨细胞，大量怪异的有丝分裂象，以及明显的红细胞吞噬现象。免疫组织化学显示肿瘤细胞对离子钙结合衔接分子1（一种组织细胞标志物）呈阳性，而对CD3（一种T细胞标志物）和髓过氧化物酶呈阴性，从而确诊为系统性组织细胞肉瘤。