Bogue C W, Wise J D, Gray G F, Edwards K M
Department of Pediatrics, Vanderbilt University School of Medicine, Children's Hospital of Vanderbilt, Nashville, Tenn 37232.
JAMA. 1989 Aug 11;262(6):813-6.
Cat-scratch disease is usually a benign, self-limited disease that causes regional lymphadenopathy. Occasionally, it may present with systemic symptoms and have a prolonged course. To date, antibiotic therapy has not been proved to be of value. We describe three patients with cat-scratch disease who were treated successfully with gentamicin sulfate. Two patients had extensive hepatic involvement, and one patient had regional lymphadenopathy. All three patients responded within 48 hours to intravenous gentamicin. Extensive follow-up has shown no recurrence of symptoms. These cases suggest that gentamicin may be efficacious in shortening the course of cat-scratch disease. Prospective, randomized trials should be performed to confirm these results.
猫抓病通常是一种良性的自限性疾病，可导致局部淋巴结病。偶尔，它可能出现全身症状且病程延长。迄今为止，抗生素治疗尚未被证明有价值。我们描述了3例用硫酸庆大霉素成功治疗的猫抓病患者。2例患者有广泛的肝脏受累，1例患者有局部淋巴结病。所有3例患者静脉注射庆大霉素后48小时内均有反应。广泛的随访显示症状无复发。这些病例表明庆大霉素可能有效缩短猫抓病的病程。应进行前瞻性随机试验以证实这些结果。
