XPC基因多态性与前列腺癌风险的关联
Association of XPC Gene Polymorphisms with Prostate Cancer Risk.
作者信息
Kahnamouei Shima A, Narouie Behzad, Sotoudeh Mehdi, Mollakouchekian Mohammad J, Simforoosh Nasser, Ziaee Seyed A M, Samzadeh Mohammad, Afshari Mahdi, Jamaldini Seyed H, Imeni Mahdieh, Hasanzad Mandana
出版信息
Clin Lab. 2016;62(6):1009-15. doi: 10.7754/clin.lab.2015.150914.
BACKGROUND
Defective DNA repair capacity caused by inherited polymorphisms could be associated with cancer susceptibility. One of the major repair pathways is Nucleotide Excision Repair (NER). We investigated Xeroderma Pigmentosum complementation group C (XPC) polymorphisms (Lys939Gln, PAT) with the risk of prostate cancer.
METHODS
154 confirmed prostate cancer patients and 205 Benign Prostate Hyperplasia (BPH) controls were recruited in this survey. The genotypes were determined by PCR-Restriction Fragment Length Polymorphism (RFLP) method.
RESULTS
Our results indicated that there were no significant differences between the BPH group and patient group for the XPC Lys939Gln in this pathway. However, deletion/insertion (D/I) and insertion/insertion (I/I) of XPC PAT polymorphism in this pathway could decrease the risk of prostate cancer and act as a protective factor.
CONCLUSIONS
In this study, XPC Lys939Gln gene polymorphism was not associated with the risk of developing prostate cancer in Iranian patients. There are no association between different alleles of this polymorphism and grades and stages of tumors, but our results indicated the significant association between XPC PAT and reduction of prostate cancer risk in this group of patients. For more significant results, further samples are required.
背景
遗传性多态性导致的DNA修复能力缺陷可能与癌症易感性相关。主要的修复途径之一是核苷酸切除修复（NER）。我们研究了着色性干皮病C互补组（XPC）多态性（Lys939Gln、PAT）与前列腺癌风险的关系。
方法
本研究招募了154例确诊的前列腺癌患者和205例良性前列腺增生（BPH）对照。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法确定基因型。
结果
我们的结果表明，在该途径中，BPH组和患者组之间的XPC Lys939Gln没有显著差异。然而，该途径中XPC PAT多态性的缺失/插入（D/I）和插入/插入（I/I）可降低前列腺癌风险并作为保护因素。
结论
在本研究中，XPC Lys939Gln基因多态性与伊朗患者患前列腺癌的风险无关。该多态性的不同等位基因与肿瘤的分级和分期之间没有关联，但我们的结果表明XPC PAT与该组患者前列腺癌风险降低之间存在显著关联。为获得更显著的结果，需要更多样本。
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