Sukhdev Singh, Bhupender Sharma, Singh Kanwar Shamsher
Department of Biotechnology, Himachal Pradesh University, Summer Hill, Shimla-171 005, India.
Mini Rev Med Chem. 2017;17(4):371-379. doi: 10.2174/1389557516666160728110911.
The humans worldwide are facing obesity as a major clinical threat because it is linked with cardiovascular diseases which often have serious consequences. Treatments available for body weight loss do not produce permanent weight loss and they often bear some side effects. To achieve safer antiobesetic therapeutics, researchers are moving towards plant-based therapeutic formulations. Many phytomolecules have been identified as anti-lipolytic functions but none of them have reached up to the clinical level. So there is an essential need to develop effective anti-obesetic medications which not only produce sufficient weight loss but also lack side effects. Plants may prove promising option for the same. In this article, medications and surgical procedures have been reviewed and dealt for weight loss and the role of phytomolecules in anti-obesetic therapeutics has been explored.
全球人类都面临着肥胖这一重大临床威胁,因为它与常常会产生严重后果的心血管疾病相关联。现有的体重减轻治疗方法并不能带来永久性体重减轻,而且往往会有一些副作用。为了实现更安全的抗肥胖疗法,研究人员正转向基于植物的治疗配方。许多植物分子已被确定具有抗脂肪分解功能,但它们都尚未达到临床应用水平。因此,迫切需要开发有效的抗肥胖药物,这些药物不仅能产生足够的体重减轻效果,而且没有副作用。植物可能被证明是实现这一目标的有前景的选择。在本文中,对减肥的药物和外科手术进行了综述和讨论,并探讨了植物分子在抗肥胖治疗中的作用。