TIFAC CORE in Herbal Drugs, Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Rockland's, Ooty, 643001, Tamil Nadu, India.
TIFAC CORE in Herbal Drugs, Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Rockland's, Ooty, 643001, Tamil Nadu, India.
Pharmacol Res. 2020 May;155:104681. doi: 10.1016/j.phrs.2020.104681. Epub 2020 Feb 8.
The prevalence of obesity is alarmingly increasing in the last few decades and leading to many serious public health concerns worldwide. The dysregulated lipid homeostasis due to various genetic, environmental and lifestyle factors is considered one of the critical putative pathways mediating obesity. Nonetheless, the scientific advancements unleashing the molecular dynamics of lipid metabolism have provided deeper insights on the emerging roles of lipid hydrolysing enzymes, including pancreatic lipase. It is hypothesized that inhibiting pancreatic lipase would prevent the breakdown of triglyceride and delays the absorption of fatty acids into the systemic circulation and adipocytes. Whilst, orlistat is the only conventional pancreatic lipase enzyme inhibitor available in clinics, identifying the safe clinical alternatives from plants to inhibit pancreatic lipase has been considered a significant advancement. Consequently, plants which have shown significant potential to combat obesity are now revisited for its abilities to inhibit pancreatic lipase. In this regard, our review surveyed the potential of medicinal plants and its phytoconstituents to inhibit pancreatic lipase and to elicit anti-obesity effects. Thus, the review collate and critically appraise the potential of medicinal plants and phyto-molecules inhibiting pancreatic lipase enzyme and consequently modulating triglyceride absorption in gut, and discuss its implications in the development of novel therapeutic strategies to combat obesity.
在过去几十年中，肥胖的患病率惊人地增加，导致全球许多严重的公共健康问题。由于各种遗传、环境和生活方式因素导致的脂质代谢失衡，被认为是介导肥胖的关键潜在途径之一。尽管如此，揭示脂质代谢分子动力学的科学进步为脂质水解酶（包括胰腺脂肪酶）的新兴作用提供了更深入的了解。据推测，抑制胰腺脂肪酶可以防止甘油三酯的分解，并延缓脂肪酸进入全身循环和脂肪细胞。虽然奥利司他是目前临床上唯一可用的常规胰腺脂肪酶抑制剂，但从植物中寻找安全的临床替代品来抑制胰腺脂肪酶已被认为是一项重大进展。因此，现在重新审视那些具有显著抗肥胖潜力的植物，以评估其抑制胰腺脂肪酶的能力。在这方面，我们的综述调查了药用植物及其植物成分抑制胰腺脂肪酶和引发抗肥胖作用的潜力。因此，该综述综述了抑制胰腺脂肪酶酶并调节肠道中甘油三酯吸收的药用植物和植物分子的潜力，并讨论了其在开发新的治疗肥胖症策略方面的意义。
