使用韩国标准系列的斑贴试验结果：一项5年回顾性研究。

Patch-test results using Korean standard series: a 5-year retrospective review.

作者信息

Yu Dong Soo, Kim Hyun Jee, Park Yong Gyu, Bae Jung Min, Kim Jin-Wou, Lee Young Bok

机构信息

a Department of Dermatology , College of Medicine, The Catholic University of Korea , Seoul , Korea.

b Department of Biostatistics , College of Medicine, The Catholic University of Korea , Seoul , Korea.

出版信息

J Dermatolog Treat. 2017 May;28(3):258-262. doi: 10.1080/09546634.2016.1219015. Epub 2016 Nov 13.

DOI:10.1080/09546634.2016.1219015

PMID:27469077

Abstract

BACKGROUND

There have been few studies regarding the results of the Korean standard patch test.

OBJECTIVES

The purpose of this study was to analyze the type and frequency of common contact allergens in Korea and to compare the results with those of previous reports.

METHODS

From June 2009 to June 2014, 330 patients with suspected allergic contact dermatitis who visited our clinic were tested using the Korean standard patch test.

RESULTS

The highest sensitization rate was found for nickel sulfate (47.58%). There was a significant gender difference in the prevalence of sensitization to nickel sulfate (OR = 2.41, p = .0004) and wool alcohol (OR = 2.85, p = .0358). Higher sensitization to nickel sulfate (OR = 1.18, p = .0159), 4-phenylenediamine (OR = 1.23, p= .003), tixocortol-21-pivalte (OR 1.48, p = .0212) and lower sensitization to thimerosal (OR = 0.77, p = .0023) were associated with increasing age. Patients with allergic contact dermatitis on the scalp had a significantly higher risk of sensitization to 4-phenylenediamine (OR = 3.07, p = .0013). Patients with allergic contact dermatitis on the hands had significantly higher risks of sensitization to wool alcohol (OR = 3.44, p = .0083), formaldehyde (OR = 2.52, p = .0178), and colophony (OR = 2.05, p = .0499).

CONCLUSIONS

These results demonstrate trends in patch test results in Korea and the basis for the presumption of the route of allergen exposure.

摘要

背景

关于韩国标准斑贴试验结果的研究较少。

目的

本研究旨在分析韩国常见接触性过敏原的类型和频率，并将结果与既往报告进行比较。

方法

2009年6月至2014年6月，对330例到我院就诊的疑似过敏性接触性皮炎患者进行韩国标准斑贴试验。

结果

硫酸镍的致敏率最高（47.58%）。硫酸镍（OR = 2.41，p = 0.0004）和羊毛醇（OR = 2.85，p = 0.0358）致敏率存在显著性别差异。随着年龄增长，硫酸镍（OR = 1.18，p = 0.0159）、对苯二胺（OR = 1.23，p = 0.003）、曲安西龙-21-新戊酸酯（OR = 1.48，p = 0.0212）致敏率升高，硫柳汞致敏率降低（OR = 0.77，p = 0.0023）。头皮过敏性接触性皮炎患者对苯二胺致敏风险显著更高（OR = 3.07，p = 0.0013）。手部过敏性接触性皮炎患者对羊毛醇（OR = 3.44，p = 0.0083）、甲醛（OR = 2.52，p = 0.0178）和松香（OR = 2.05，p = 0.0499）致敏风险显著更高。