Northeastern University, School of Information Science and Engineering, No. 11 Lane Three Culture Road, Heping Area, Shenyang 110819, China.
Capital Medical University, Department of Neurology, Xuan Wu Hospital, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
J Biomed Opt. 2016 Jul 1;21(7):75014. doi: 10.1117/1.JBO.21.7.075014.
A blockage of the middle cerebral artery (MCA) on the cortical branch will seriously affect the blood supply of the cerebral cortex. Real-time monitoring of MCA hemodynamic parameters is critical for therapy and rehabilitation. Optical coherence tomography (OCT) is a powerful imaging modality that can produce not only structural images but also functional information on the tissue. We use OCT to detect hemodynamic changes after MCA branch occlusion. We injected a selected dose of endothelin-1 (ET-1) at a depth of 1 mm near the MCA and let the blood vessels follow a process first of occlusion and then of slow reperfusion as realistically as possible to simulate local cerebral ischemia. During this period, we used optical microangiography and Doppler OCT to obtain multiple hemodynamic MCA parameters. The change trend of these parameters from before to after ET-1 injection clearly reflects the dynamic regularity of the MCA. These results show the mechanism of the cerebral ischemia-reperfusion process after a transient middle cerebral artery occlusion and confirm that OCT can be used to monitor hemodynamic parameters.
大脑中动脉（MCA）皮质分支的阻塞会严重影响大脑皮层的血液供应。实时监测 MCA 血流动力学参数对治疗和康复至关重要。光学相干断层扫描（OCT）是一种强大的成像方式，不仅可以产生组织结构图像，还可以提供组织的功能信息。我们使用 OCT 来检测 MCA 分支闭塞后的血流动力学变化。我们在 MCA 附近 1 毫米的深度注射了选定剂量的内皮素-1（ET-1），让血管尽可能真实地经历阻塞和缓慢再灌注的过程，以模拟局部脑缺血。在此期间，我们使用光学微血管造影和多普勒 OCT 获得多个 MCA 血流动力学参数。这些参数从 ET-1 注射前后的变化趋势清楚地反映了 MCA 的动态规律。这些结果显示了短暂性大脑中动脉闭塞后脑缺血再灌注过程的机制，并证实 OCT 可用于监测血流动力学参数。
