Blackman Scott M, Tangpricha Vin
Division of Pediatric Endocrinology, Department of Pediatrics, Johns Hopkins Hospital, Johns Hopkins University, 200 North Wolfe Street, Baltimore, MD 21287, USA.
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Atlanta VA Medical Center, Emory University School of Medicine, 101 Woodruff Circle NE, WMRB1301, Atlanta, GA 30322, USA.
Pediatr Clin North Am. 2016 Aug;63(4):699-708. doi: 10.1016/j.pcl.2016.04.009.
Cystic fibrosis is frequently complicated by endocrine disorders. Diabetes can be expected to affect most with CF and pancreatic insufficiency and varies widely in age of onset, but early identification and treatment improve morbidity and mortality. Short stature can be exacerbated by relative delay of puberty and by use of inhaled corticosteroids. Bone disease in CF causes fragility fractures and should be assessed by monitoring bone mineral density and optimizing vitamin D status. Detecting and managing endocrine complications in CF can reduce morbidity and mortality in CF. These complications can be expected to become more common as the CF population ages.
囊性纤维化常并发内分泌紊乱。预计大多数患有囊性纤维化且伴有胰腺功能不全的患者会出现糖尿病，其发病年龄差异很大，但早期识别和治疗可改善发病率和死亡率。青春期相对延迟以及使用吸入性糖皮质激素会加剧身材矮小。囊性纤维化患者的骨病会导致脆性骨折，应通过监测骨密度和优化维生素D状态进行评估。检测和管理囊性纤维化患者的内分泌并发症可降低其发病率和死亡率。随着囊性纤维化患者群体的老龄化，这些并发症预计会变得更加常见。
