a Department of Food Science , Cornell University , Ithaca , New York , USA.
Crit Rev Food Sci Nutr. 2018 Mar 4;58(4):568-574. doi: 10.1080/10408398.2016.1203755. Epub 2017 Oct 4.
There are growing interests in the health benefits associated with consumption of fruits and vegetables, especially for the prevention of cancer, cardiovascular, or other chronic diseases. Epidemiological studies and clinical trials suggest that these health benefits are strongly associated with phytochemicals found in fruits and vegetables. Ursolic acid is a naturally synthesized pentacyclic triterpenoid, widely distributed in different fruits and vegetables. Current research suggested that ursolic acid and its derivatives exhibited anticancer activity, anti-inflammatory effects, and induction of apoptosis in several human cancer cells. In particular, ursolic acid inhibited breast cancer proliferation by inducing cell G1/G2 arrest and regulating the expression of key proteins in signal transduction pathways. In addition, ursolic acid induced apoptosis in human breast cancer cells through intrinsic and extrinsic apoptotic pathways. Ursolic acid was also determined to scavenge free radicals and have potent anti-inflammation activity. The purpose of this paper is to review recent literature on anticancer activity of ursolic acid and focus on its mechanisms of action.
人们越来越关注食用水果和蔬菜带来的健康益处，尤其是对癌症、心血管或其他慢性疾病的预防。流行病学研究和临床试验表明，这些健康益处与水果和蔬菜中含有的植物化学物质密切相关。熊果酸是一种天然合成的五环三萜，广泛分布于不同的水果和蔬菜中。目前的研究表明，熊果酸及其衍生物在几种人类癌细胞中表现出抗癌活性、抗炎作用和诱导细胞凋亡。特别是，熊果酸通过诱导细胞 G1/G2 期阻滞和调节信号转导通路中关键蛋白的表达来抑制乳腺癌的增殖。此外，熊果酸通过内在和外在的凋亡途径诱导人乳腺癌细胞凋亡。熊果酸还被确定能清除自由基和具有很强的抗炎活性。本文的目的是综述熊果酸的抗癌活性的最新文献，并重点介绍其作用机制。
