Takano Y, Hayashi N, Toshitani S, Soji T
Nihon Hifuka Gakkai Zasshi. 1989 Jan;99(1):67-71.
A 25-year-old man had multiple subcutaneous nodules on the neck, trunk and extremities. Those nodules first appeared in the right popliteal fossa about 15 years ago and thereafter gradually increased in the number with hearing loss, tinnitus, and vertigo. The tumors had smooth surfaces and were elastic hard without any adhesion to the overlying skin or to subcutaneous tissue. Histological examination revealed, in most parts of the lesion, Antoni type A neurilemmoma and the Antoni type B picture at the periphery. As extracutaneous lesion, there were bilateral cerebello-pontine angle neurilemmomas, and spinal and adrenal tumors. Similar subcutaneous tumors have been recognized in 6 of 17 family members of the previous four generations of his family. According to a statistical analysis of 119 cases, including this one, in the Japanese dermatological field, of 75 cases of solitary neurilemmoma and 44 cases of multiple ones, the latter showed male predominance and lower age of the onset. Many of them had tumors not only in the skin but also in extracutaneous sites.
一名25岁男性在颈部、躯干和四肢有多个皮下结节。这些结节大约15年前首次出现在右腘窝，此后数量逐渐增加，并伴有听力丧失、耳鸣和眩晕。肿瘤表面光滑，质地硬且有弹性，与覆盖皮肤或皮下组织无粘连。组织学检查显示，病变大部分区域为Antoni A型神经鞘瘤，周边为Antoni B型表现。作为皮肤外病变，有双侧桥小脑角神经鞘瘤、脊柱和肾上腺肿瘤。在他家族前四代的17名家庭成员中，有6人也发现了类似的皮下肿瘤。根据日本皮肤科领域包括本例在内的119例病例的统计分析，75例孤立性神经鞘瘤和44例多发性神经鞘瘤中，后者男性居多且发病年龄较低。他们中许多人不仅皮肤有肿瘤，皮肤外部位也有肿瘤。
