Moghaddasi Mehrnoush, Taati Majid, Asadian Payman, Khalatbary Ali Reza, Asaei Raheleh, Pajouhi Naser
Department of Physiology, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorramabad, Iran.
J Physiol Sci. 2017 May;67(3):415-423. doi: 10.1007/s12576-016-0474-z. Epub 2016 Jul 28.
The purpose of this study was to evaluate the effects of cerebral hypoperfusion on cognitive ability, TNFα, IL1β and PGE2 levels in both hippocampi in a modified two-vessel occlusion model. Both common carotid arteries of adult male Wistar rats were permanently occluded with an interval of 1 week between occlusions. Learning and memory were significantly decreased after 1 month. This reduction was not significant after 2 months, which may be attributed to blood flow compensation. The TNFα level was significantly increased after 3 h and 1 day. IL1β was significantly increased after 1 day. After a week there was no significant difference in pro-inflammatory levels. Furthermore, there was no difference between right and left hippocampi. It is possible that TNFα and IL1β elevation initiates pathologic processes that contribute to memory impairment.
本研究的目的是在改良的双血管闭塞模型中,评估脑灌注不足对双侧海马认知能力、肿瘤坏死因子α(TNFα)、白细胞介素1β(IL1β)和前列腺素E2(PGE2)水平的影响。成年雄性Wistar大鼠的双侧颈总动脉被永久性闭塞,闭塞间隔为1周。1个月后学习和记忆能力显著下降。2个月后这种下降不显著,这可能归因于血流代偿。3小时和1天后TNFα水平显著升高。1天后IL1β显著升高。1周后促炎水平无显著差异。此外,左右海马之间没有差异。TNFα和IL1β升高可能引发导致记忆障碍的病理过程。