Physiology Research Center, Department of Physiology, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
Psychopharmacology (Berl). 2021 Mar;238(3):877-886. doi: 10.1007/s00213-020-05739-x. Epub 2021 Jan 6.
Memory deficit is a common cognitive comorbid in patients with neuropathic pain that need better treatment. Recent research revealed that nanocurcumin has an antinociceptive action and a protective effect against memory disorders, suggesting its possible effectiveness for the treatment of neuropathic pain and its comorbidity.
Adult male albino Wistar rats (n = 32) were randomly divided into four experimental groups: CCI+ nanocurcumin, CCI + vehicle, sham + nanocurcumin, and sham + vehicle. Neuropathic pain induced by a chronic constriction injury of the sciatic nerve. Nanocurcumin or vehicle was injected intraperitoneally for 10 days. Behavioral assessment achieved to evaluate pain threshold in the von Frey test and radiant heat test, also spatial learning and memory examined by the Morris water maze (MWM) test. To explore the possible relation, IL-1β, and TNF-α levels of the hippocampus measured by enzyme-linked immunosorbent assay (ELISA).
Our data showed that CCI caused neuropathic pain-related behaviors and spatial learning and memory disorders in rats. Chronic treatment with nanocurcumin significantly increased pain threshold (P < 0.001; F = 27.63, F = 20.58), improved spatial memory (P < 0.01; F = 47.37), and decreased the hippocampal levels of IL-1β (P < 0.001; F = 33.57) and TNF-α (P < 0.01; F = 7.25) in CCI rats.
Chronic nanocurcumin can ameliorate pain-related behavior, improve spatial learning and memory deficits, and is associated with the reduction of IL-1β and TNF-α levels in the hippocampus in CCI rats. Nanocurcumin may be potentially providing a therapeutic alternative for the treatment of neuropathic pain and its memory impairment comorbidity.
记忆缺陷是神经病理性疼痛患者常见的认知合并症，需要更好的治疗。最近的研究表明，纳米姜黄素具有镇痛作用和对记忆障碍的保护作用，这表明它可能对治疗神经病理性疼痛及其合并症有效。
成年雄性白化 Wistar 大鼠（n = 32）随机分为四组：CCI+纳米姜黄素组、CCI+载体组、假手术+纳米姜黄素组和假手术+载体组。坐骨神经慢性缩窄性损伤诱导神经病理性疼痛。纳米姜黄素或载体腹膜内注射 10 天。通过 von Frey 试验和辐射热试验评估疼痛阈值，通过 Morris 水迷宫（MWM）试验评估空间学习和记忆。通过酶联免疫吸附试验（ELISA）测量海马体中的 IL-1β 和 TNF-α 水平，以探索可能的关系。
我们的数据表明，CCI 导致大鼠出现神经病理性疼痛相关行为和空间学习记忆障碍。慢性纳米姜黄素治疗显著增加疼痛阈值（P < 0.001；F = 27.63，F = 20.58），改善空间记忆（P < 0.01；F = 47.37），并降低 CCI 大鼠海马体中的 IL-1β（P < 0.001；F = 33.57）和 TNF-α（P < 0.01；F = 7.25）水平。
慢性纳米姜黄素可改善与疼痛相关的行为，改善空间学习和记忆障碍，并与 CCI 大鼠海马体中 IL-1β 和 TNF-α 水平的降低有关。纳米姜黄素可能为治疗神经病理性疼痛及其记忆障碍合并症提供潜在的治疗选择。
