[Motor function of the stomach and small intestine and gastric secretory activity in smokers and alcoholic patients with duodenal ulcer].

The dependence of the parameters of the electromyogastroenterogram, basal and maximal histamine secretion of HCl and pepsin on alcohol consumption and smoking (separately and in combination) was studied in 248 duodenal ulcer patients. The amplitude parameters of the digestive motor gastric and small intestinal function, HCl secretion in the basal period and in response to maximal histamine stimulation were found to be significantly increased in habitual alcoholics and smokers, while the level of the basal and stimulated pepsin secretion in smokers was also increased. In addition, in 15 males without ulcer a single intake of large doses of alcoholic drinks containing more than 200 g of ethanol caused significant increase in the amplitude parameters of the electromyogastroenterogram which normalized in 48 hours. Since alcohol and smoking significantly enhance hypermotor gastroenteral dyskinesis and gastric hypersecretion in duodenal ulcer patients, prophylaxis and treatment should be aimed at the removal of these factors.