自噬对人乳腺癌细胞局部免疫监视的积极影响。
Positive impact of autophagy in human breast cancer cells on local immunosurveillance.
作者信息
Ladoire Sylvain, Enot David, Senovilla Laura, Chaix Marie, Zitvogel Laurence, Kroemer Guido
机构信息
Department of Medical Oncology, Georges François Leclerc Center, Dijon, France; Institut National de la Santé et de la Recherche Médicale, U1015, Equipe labellisée Ligue Nationale Contre le Cancer, Institut Gustave Roussy, Villejuif, France.
Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus , Villejuif, France.
出版信息
Oncoimmunology. 2016 May 24;5(6):e1174801. doi: 10.1080/2162402X.2016.1174801. eCollection 2016 Jun.
Abstract
In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B(+) puncta within malignant cells positively correlate with the intratumoral abundance of CD8(+) cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3(+) regulatory T cells and CD68(+) tumor-associated macrophages, resulting in an improvement of CD8(+)/FOXP(+) or CD8(+)/CD68(+) ratios.
摘要
在人类乳腺癌细胞中，微管相关蛋白1A/1B轻链3B（LC3B）呈阳性的胞质点的存在表明自噬通量增强且预后良好。恶性细胞内的LC3B（+）斑点与肿瘤内CD8（+）细胞毒性T淋巴细胞的丰度呈正相关，但与局部FOXP3（+）调节性T细胞和CD68（+）肿瘤相关巨噬细胞的频率呈负相关，从而导致CD8（+）/FOXP（+）或CD8（+）/CD68（+）比值升高。
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