Cascino G D, Jensen J M, Nelson L A, Schutta H S
Department of Neurology, Mayo Clinic, Rochester, MN 55905.
Mayo Clin Proc. 1989 Jun;64(6):653-6. doi: 10.1016/s0025-6196(12)65343-9.
Ureterosigmoidostomy, a urinary diversion procedure performed for treatment congenital urologic defects or bladder cancer, may be associated with hyperammonemia. A delayed periodic encephalopathy, characterized by dysarthria, ataxia, and coma, developed in a 44-year-old woman who had undergone this procedure. Hyperammonemia-associated neurotoxicity resolved after surgical revision of the ureterosigmoidostomy to a uretero-ileostomy. Therefore, a treatable episodic encephalopathy may occur in association with hyperammonemia in patients who have undergone ureterosigmoidostomy.
输尿管乙状结肠吻合术是一种用于治疗先天性泌尿系统缺陷或膀胱癌的尿流改道术，可能与高氨血症有关。一名接受过该手术的44岁女性出现了一种迟发性周期性脑病，其特征为构音障碍、共济失调和昏迷。将输尿管乙状结肠吻合术改为输尿管回肠造口术后，高氨血症相关的神经毒性得到缓解。因此，接受输尿管乙状结肠吻合术的患者可能会出现与高氨血症相关的可治疗性发作性脑病。
