Johnson Jacob K, Laughon Matthew M
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Clin Ther. 2016 Sep;38(9):1948-60. doi: 10.1016/j.clinthera.2016.06.017. Epub 2016 Jul 26.
The goal of this article was to review infant physiology and its effects on the pharmacokinetic properties of antimicrobial agents.
A review of the drug development process was performed. A literature search was conducted on the pharmacokinetics of various antimicrobial agents in infants.
The pharmacokinetic properties of antimicrobial agents in infants are most often affected by the renal maturation of premature infants. Hepatic metabolism and volume of distribution play a common role as well.
The dosing and dosing intervals of various medications were reviewed and compared with details of adult dosing. It is vital to continue to gather pharmacokinetic data in infants to ensure adequate safety and dosing of medications.
本文的目的是回顾婴儿生理学及其对抗菌药物药代动力学特性的影响。
对药物研发过程进行了回顾。对各种抗菌药物在婴儿体内的药代动力学进行了文献检索。
抗菌药物在婴儿体内的药代动力学特性最常受到早产儿肾脏成熟度的影响。肝脏代谢和分布容积也起共同作用。
对各种药物的给药剂量和给药间隔进行了回顾，并与成人给药细节进行了比较。持续收集婴儿的药代动力学数据以确保药物的充分安全性和给药剂量至关重要。
