Kloosterman Mariëlle, Rienstra Michiel, Van Gelder Isabelle C, Maass Alexander H
Department of Cardiology, Thoraxcenter, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Cardiology, Thoraxcenter, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
J Electrocardiol. 2016 Sep-Oct;49(5):696-8. doi: 10.1016/j.jelectrocard.2016.07.008. Epub 2016 Jul 15.
Left bundle branch block (LBBB) is considered a marker of underlying structural cardiac disease. To determine whether LBBB is cause or consequence of deterioration of left ventricular (LV) function is difficult as both are often diagnosed concomitantly. We discuss a patient where reversal of LBBB and subsequent normalization of LV function was observed after 2 different therapies, first after start of heart failure medication, and years later after implantation of a cardiac resynchronization device. This indicates that LBBB per se may result in the development of non-ischemic cardiomyopathy and that LBBB resolution can lead to reverse remodeling in dyssynchronopathy.
左束支传导阻滞（LBBB）被认为是潜在结构性心脏病的一个标志。由于左束支传导阻滞和左心室（LV）功能恶化往往同时被诊断出来，因此很难确定左束支传导阻滞是左心室功能恶化的原因还是结果。我们讨论了一位患者，在两种不同治疗后观察到左束支传导阻滞的逆转以及随后左心室功能的恢复正常，第一次是在开始使用心力衰竭药物后，数年后是在植入心脏再同步装置后。这表明左束支传导阻滞本身可能导致非缺血性心肌病的发生，并且左束支传导阻滞的消除可导致心脏不同步疾病的逆向重塑。
