Vermeer Jenny A F, Renders Greetje A P, Everts Vincent
Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
Curr Osteoporos Rep. 2016 Oct;14(5):219-25. doi: 10.1007/s11914-016-0318-z.
A known complication that can occur in patients using bisphosphonates (BPs) is osteonecrosis of the jaw (ONJ). ONJ features bone exposure that may be associated with severe pain, swelling, local infection, and pathological fracture of the jaw. Current literature indicates that a complex combination of factors is necessary to induce ONJ. Several hypotheses about the pathophysiology of ONJ were previously reported. Here, we review these hypotheses and introduce new ideas and suggestions on this topic, focusing on bone site-specific cells, and the effect that BPs and other anti-resorptive drugs have on those cells. Gaining more insight into bone site-specific effects may help to better understand the pathogenesis ONJ, and contribute to the development of new bone site-specific anti-resorptive drugs.
使用双膦酸盐（BP）的患者可能会出现一种已知的并发症，即颌骨坏死（ONJ）。ONJ的特征是骨暴露，可能伴有严重疼痛、肿胀、局部感染和颌骨病理性骨折。目前的文献表明，诱发ONJ需要多种因素的复杂组合。此前曾报道过关于ONJ病理生理学的几种假说。在此，我们回顾这些假说，并就该主题提出新的观点和建议，重点关注骨位点特异性细胞，以及BP和其他抗吸收药物对这些细胞的影响。更深入地了解骨位点特异性效应可能有助于更好地理解ONJ的发病机制，并有助于开发新的骨位点特异性抗吸收药物。
