Niigata University, Japan.
Dokkyo Medical University, Shimotsuga, Japan.
J Atten Disord. 2020 Feb;24(3):490-493. doi: 10.1177/1087054716661235. Epub 2016 Jul 28.
The objective was to reveal the relationship between dose and concentration of atomoxetine. Fifty-five blood samples of 33 patients with ADHD were examined using high-performance liquid chromatography. The plasma concentrations were 53.2 ± 67.0, 298.0 ± 390.5, and 639.3 ± 831.9 ng/mL at doses of 40 mg, 80 mg, and 120 mg, and the concentration/dose were 1.33 ± 1.67, 3.73 ± 4.88, and 5.33 ± 6.93 ng/mL/mg, respectively. Statistical analyses revealed a significant correlation between the concentration and the dose of atomoxetine ( = .004), and a trending toward significance in the difference in the concentration/dose in the three dosage groups ( = .064). The concentration/dose at 40 and 80 + 120 mg/day were 1.33 ± 1.67 and 4.22 ± 5.53 ng/mL/mg, the latter was significantly higher than the former ( = .006), which suggested non-linear pharmacokinetics. Clinicians should carefully titrate in high dose atomoxetine treatment.
目的在于揭示阿托西汀剂量与浓度之间的关系。采用高效液相色谱法对 33 例 ADHD 患者的 55 份血样进行了检测。在剂量为 40mg、80mg 和 120mg 时，患者的血浆浓度分别为 53.2±67.0ng/ml、298.0±390.5ng/ml 和 639.3±831.9ng/ml，浓度/剂量分别为 1.33±1.67ng/ml/mg、3.73±4.88ng/ml/mg 和 5.33±6.93ng/ml/mg。统计分析显示，阿托西汀的浓度与剂量之间存在显著相关性（ =.004），且在三个剂量组中，浓度/剂量的差异呈显著趋势（ =.064）。40mg 和 80mg+120mg 日剂量时的浓度/剂量分别为 1.33±1.67ng/ml/mg 和 4.22±5.53ng/ml/mg，后者明显高于前者（ =.006），提示存在非线性药代动力学。临床医生在进行高剂量阿托西汀治疗时应谨慎滴定。
