Rodrigues J N, Zhang W, Scammell B E, Chakrabarti I, Russell P G, Fullilove S, Davidson D, Davis T R C
1 Nuffield Department of Orthopaedics, University of Oxford, Oxford, UK.
2 Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham & Nottingham University Hospitals NHS Trust, Nottingham, UK.
J Hand Surg Eur Vol. 2017 Jan;42(1):7-17. doi: 10.1177/1753193416660045. Epub 2016 Jul 29.
Variables associated with recurrent Dupuytren's disease, or a 'diathesis', have been investigated, but those associated with functional outcome and complications are less well studied. Outcomes 1 or 5 years after an aponeurotomy, fasciectomy or dermofasciectomy were assessed by patient interview and examination at five UK centres. A total of 432 procedures were studied. The reoperation rate did not differ at 1 year ( p = 0.396, Chi-square test with Monte Carlo simulation), but was higher after aponeurotomy in the 5-year group (30%, versus 6% after fasciectomy and 0% after dermofasciectomy, p = 0.003, Chi square test with Monte Carlo simulation). Loss of function (DASH>15) did not differ between procedures at 5 years, even when reoperation and other variables were controlled. Diabetes, female gender and previous ipsilateral surgery were associated with poorer function in logistic regression analysis. The variables associated with poor function after treatments differ from diathesis variables. Aponeurotomy had lower complication rates than fasciectomy and dermofasciectomy. This may counterbalance the former's higher recurrence rate and explain why aponeurotomy demonstrated similar long-term functional outcome compared with excisional surgery in this study.
III.
与复发性掌腱膜挛缩症或“素质”相关的变量已得到研究,但与功能结局和并发症相关的变量研究较少。在英国的五个中心,通过患者访谈和检查评估了腱膜切开术、筋膜切除术或真皮筋膜切除术1年或5年后的结局。共研究了432例手术。1年时再次手术率无差异(p = 0.396,采用蒙特卡洛模拟的卡方检验),但在5年组中腱膜切开术后再次手术率更高(30%,而筋膜切除术后为6%,真皮筋膜切除术后为0%,p = 0.003,采用蒙特卡洛模拟的卡方检验)。即使在控制了再次手术和其他变量的情况下,5年时各手术之间功能丧失(DASH>15)无差异。在逻辑回归分析中,糖尿病、女性性别和既往同侧手术与较差的功能相关。治疗后与功能不良相关的变量不同于素质变量。腱膜切开术的并发症发生率低于筋膜切除术和真皮筋膜切除术。这可能抵消了前者较高的复发率,并解释了为什么在本研究中腱膜切开术与切除手术相比显示出相似的长期功能结局。
III级。