基于木聚糖的温度/ pH 敏感水凝胶用于药物控制释放。
Xylan-based temperature/pH sensitive hydrogels for drug controlled release.
机构信息
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, Guangdong, China.
出版信息
Carbohydr Polym. 2016 Oct 20;151:189-197. doi: 10.1016/j.carbpol.2016.05.075. Epub 2016 May 24.
Xylan-based temperature/pH sensitive hydrogels were prepared by the crosslinking copolymerization of xylan with N-isopropylacrylamide (NIPAm) and acrylic acid (AA) using N,Ń-methylenebis-acrylamide (MBA) as a cross-linker and 2,2-dimethoxy-2-phenylacetophenone as a photoinitiator via ultraviolet irradiation. The influence of the NIPAm, AA and MBA amount on properties of xylan-based hydrogels was discussed. The morphology and interactions of hydrogels were characterized by SEM and FTIR. The lower critical solution temperature (LCST) of hydrogels was investigated by DSC. The results indicated that the LCST of hydrogels emerged at around 34°C and increased with increasing the AA content. The drug encapsulation efficiency of as-prepared hydrogels reached to 97.60% and the cumulative release rate of acetylsalicylic acid was 90.12% and 26.35% in the intestinal and gastric fluid, respectively. Xylan-based hydrogels were proved to be biocompatible with NIH3T3 cell by MTT assay and showed the promising application as drug carriers for the intestinal-targeted oral drug delivery.
木聚糖基温/ pH 敏感水凝胶是通过木聚糖与 N-异丙基丙烯酰胺（NIPAm）和丙烯酸（AA）的交联共聚制备的，使用 N，N-亚甲基双丙烯酰胺（MBA）作为交联剂和 2,2-二甲氧基-2-苯乙酮作为光引发剂通过紫外光照射。讨论了 NIPAm、AA 和 MBA 用量对木聚糖基水凝胶性能的影响。通过 SEM 和 FTIR 对水凝胶的形态和相互作用进行了表征。通过 DSC 研究了水凝胶的低临界溶解温度（LCST）。结果表明，水凝胶的 LCST 在 34°C 左右出现，并随 AA 含量的增加而增加。所制备的水凝胶的药物包封效率达到 97.60%，乙酰水杨酸在肠液和胃液中的累积释放率分别为 90.12%和 26.35%。MTT 测定法证明木聚糖基水凝胶与 NIH3T3 细胞具有生物相容性，并显示出作为用于肠道靶向口服药物递送的药物载体的应用前景。
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