da Costa Ribeiro Andresa, T Tominaga Tania, Moretti Bonadio Taiana G, P da Silveira Nádya, C Leite Daiani
Applied Physics in Materials Group, Departamento de Física, Universidade Estadual do Centro-Oeste, Guarapuava, PR 85040-167, Brazil.
Post Graduation Program in Chemistry (PPGQ), Chemistry Institute, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 91501-970, Brazil.
ACS Omega. 2024 Jun 11;9(25):27349-27357. doi: 10.1021/acsomega.4c01947. eCollection 2024 Jun 25.
Hybrid microgels made from starch nanoparticles (SNPs) and poly(-isopropylacrylamide) p(NIPAM) were used as promising hosts for the methylene blue (MB) dye. In this paper, these thermoresponsive microgels were characterized by dynamic light scattering (DLS), zeta potential measurements (ZP), and scanning electron microscopy (SEM) and evaluated as carriers for skin-targeted drug delivery. The hybrid microgel-MB systems in PBS solution were also studied by UV-vis spectroscopy and DLS, revealing discernible differences in spectral intensity and absorption shifts compared to microgels devoid of MB. This underscores the successful integration of methylene blue within the SNPs--p(NIPAM) microgels, signifying their potential as efficacious drug delivery vehicles.
由淀粉纳米颗粒（SNP）和聚（N-异丙基丙烯酰胺）p（NIPAM）制成的杂化微凝胶被用作亚甲基蓝（MB）染料的理想载体。在本文中，这些热响应性微凝胶通过动态光散射（DLS）、zeta电位测量（ZP）和扫描电子显微镜（SEM）进行表征，并作为皮肤靶向给药载体进行评估。还通过紫外-可见光谱和DLS研究了PBS溶液中的杂化微凝胶-MB系统，结果显示与不含MB的微凝胶相比，光谱强度和吸收位移存在明显差异。这突出了亚甲基蓝在SNP-p（NIPAM）微凝胶中的成功整合，表明它们作为有效给药载体的潜力。
