College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
Carbohydr Polym. 2016 Oct 20;151:1006-1011. doi: 10.1016/j.carbpol.2016.06.055. Epub 2016 Jun 16.
A facile controlled-release nanogels delivery system has been developed by using hydroxypropyl methylcellulose (HPMC) hybrid nanogels as encapsulation shell materials, which were synthesized by surfactant-free polymerization in aqueous solution. The effects of reaction time and cross-linker concentration on the size of the nanogels have been studied. The results showed that in a certain range, the particle size decreased with increasing reaction time and increasing concentration of cross-linker. Meanwhile, at the feeding ratio 0.05/1 of HPMC/methacrylic acid (MAA), the LCST of prepared nanogels at pH=6 was close to the body temperature, which can be used as sustained insulin delivery system. Besides, the HPMC nanogels loaded with insulin had a high drug loading of 21.3% and a high entrapment efficiency of 95.7%. The release behavior of the insulin nanogels can be adjusted by pH and temperature which will have potential applications in controlled release delivery system.
已开发出一种简便的控释纳米凝胶输送系统，该系统使用羟丙基甲基纤维素（HPMC）混合纳米凝胶作为封装壳材料，通过在水溶液中的无表面活性剂聚合合成。研究了反应时间和交联剂浓度对纳米凝胶尺寸的影响。结果表明，在一定范围内，粒径随反应时间的增加和交联剂浓度的增加而减小。同时，在 HPMC/甲基丙烯酸（MAA）进料比为 0.05/1 的情况下，在 pH=6 时制备的纳米凝胶的 LCST 接近体温，可作为胰岛素的持续释放系统。此外，负载胰岛素的 HPMC 纳米凝胶具有 21.3%的高载药量和 95.7%的高包封效率。胰岛素纳米凝胶的释放行为可以通过 pH 和温度进行调节，这将在控制释放输送系统中有潜在的应用。
