无表面活性剂的羟丙基甲基纤维素纳米凝胶的合成及其用于胰岛素的控制释放。
Synthesis of surfactant-free hydroxypropyl methylcellulose nanogels for controlled release of insulin.
机构信息
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China.
出版信息
Carbohydr Polym. 2016 Oct 20;151:1006-1011. doi: 10.1016/j.carbpol.2016.06.055. Epub 2016 Jun 16.
A facile controlled-release nanogels delivery system has been developed by using hydroxypropyl methylcellulose (HPMC) hybrid nanogels as encapsulation shell materials, which were synthesized by surfactant-free polymerization in aqueous solution. The effects of reaction time and cross-linker concentration on the size of the nanogels have been studied. The results showed that in a certain range, the particle size decreased with increasing reaction time and increasing concentration of cross-linker. Meanwhile, at the feeding ratio 0.05/1 of HPMC/methacrylic acid (MAA), the LCST of prepared nanogels at pH=6 was close to the body temperature, which can be used as sustained insulin delivery system. Besides, the HPMC nanogels loaded with insulin had a high drug loading of 21.3% and a high entrapment efficiency of 95.7%. The release behavior of the insulin nanogels can be adjusted by pH and temperature which will have potential applications in controlled release delivery system.
已开发出一种简便的控释纳米凝胶输送系统，该系统使用羟丙基甲基纤维素（HPMC）混合纳米凝胶作为封装壳材料，通过在水溶液中的无表面活性剂聚合合成。研究了反应时间和交联剂浓度对纳米凝胶尺寸的影响。结果表明，在一定范围内，粒径随反应时间的增加和交联剂浓度的增加而减小。同时，在 HPMC/甲基丙烯酸（MAA）进料比为 0.05/1 的情况下，在 pH=6 时制备的纳米凝胶的 LCST 接近体温，可作为胰岛素的持续释放系统。此外，负载胰岛素的 HPMC 纳米凝胶具有 21.3%的高载药量和 95.7%的高包封效率。胰岛素纳米凝胶的释放行为可以通过 pH 和温度进行调节，这将在控制释放输送系统中有潜在的应用。
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