Zhao Yuanfang, Li Jingguang, Liu Xiqin, Song Yiying, Wang Ruosi, Yang Zetian, Liu Jia
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing 100875, China.
College of Education, Dali University, Dali 671003, China.
Neuropsychologia. 2016 Aug;89:344-355. doi: 10.1016/j.neuropsychologia.2016.05.027. Epub 2016 Jul 28.
Individuals with developmental prosopagnosia (DP) exhibit severe difficulties in recognizing faces and to a lesser extent, also exhibit difficulties in recognizing non-face objects. We used fMRI to investigate whether these behavioral deficits could be accounted for by altered spontaneous neural activity. Two aspects of spontaneous neural activity were measured: the intensity of neural activity in a voxel indexed by the fractional amplitude of spontaneous low-frequency fluctuations (fALFF), and the connectivity of a voxel to neighboring voxels indexed by regional homogeneity (ReHo). Compared with normal adults, both the fALFF and ReHo values within the right occipital face area (rOFA) were significantly reduced in DP subjects. Follow-up studies on the normal adults revealed that these two measures indicated further functional division of labor within the rOFA. The fALFF in the rOFA was positively correlated with behavioral performance in recognition of non-face objects, whereas ReHo in the rOFA was positively correlated with processing of faces. When considered together, the altered fALFF and ReHo within the same region (rOFA) may account for the comorbid deficits in both face and object recognition in DPs, whereas the functional division of labor in these two measures helps to explain the relative independency of deficits in face recognition and object recognition in DP.
患有发展性面孔失认症（DP）的个体在识别面孔方面存在严重困难，并且在较小程度上，在识别非面孔物体时也存在困难。我们使用功能磁共振成像（fMRI）来研究这些行为缺陷是否可以由自发神经活动的改变来解释。我们测量了自发神经活动的两个方面：通过自发低频波动分数振幅（fALFF）索引的体素中的神经活动强度，以及通过局部一致性（ReHo）索引的体素与相邻体素的连通性。与正常成年人相比，DP受试者右侧枕叶面孔区（rOFA）内的fALFF和ReHo值均显著降低。对正常成年人的后续研究表明，这两种测量方法表明rOFA内存在进一步的功能分工。rOFA中的fALFF与非面孔物体识别中的行为表现呈正相关，而rOFA中的ReHo与面孔加工呈正相关。综合考虑，同一区域（rOFA）内fALFF和ReHo的改变可能解释了DP患者在面孔和物体识别方面的共病缺陷，而这两种测量方法中的功能分工有助于解释DP患者在面孔识别和物体识别方面缺陷的相对独立性。
