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冻干股骨近端异体骨在股骨柄翻修中的应用

Freeze Dried Proximal Femoral Allografts in Revision of Femoral Stems.

作者信息

Ilyas Imran, Alrumaih Husam, Rabbani Samar

机构信息

Department of Orthopedic Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Associate Professor at Alfaisal University, College of Medicine, Riyadh, Saudi Arabia.

Department of Orthopedic Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

出版信息

J Arthroplasty. 2017 Jan;32(1):171-176. doi: 10.1016/j.arth.2016.06.016. Epub 2016 Jun 22.

Abstract

BACKGROUND

Femoral bone deficiency is a challenging problem in revision femoral arthroplasty in younger patients. We evaluated outcomes of revision femoral arthroplasty using a freeze-dried allograft prosthetic composite (APC).

METHODS

This was a retrospective review of 16 patients (12 men and 4 women) who had unilateral proximal femoral deficiencies (Paprosky type III B, 13 patients; type IV, 3 patients) revised with freeze-dried APC. Follow-up at mean 7 years included assessment with Merle D'Aubigné score and radiographs.

RESULTS

At follow-up, the average hip score was improved for pain, function, and range of motion. The 5-year graft survival was 87%, and the estimated median survival was 8.8 years. There were 3 patients who walked without support, 10 patients who walked unlimited distance with a cane, 2 patients who walked with 2 crutches, and 1 patient who walked with a walker. Radiographs showed nonunion at the graft-host junction in 3 hips (19%), but only 1 patient was symptomatic. Asymptomatic trochanteric nonunion was observed in 4 hips (25%). There was moderate graft resorption in 2 patients at 9 years after surgery and mild graft resorption in 1 graft at 7 years. There was subsidence of <2 cm in 2 patients and 3.5 cm in 1 patient.

CONCLUSION

The present study showed acceptable results in treatment of major femoral deficiencies using freeze-dried APC in younger patients. Freeze-dried APC may be a useful for revision femoral arthroplasty.

摘要

背景

股骨骨缺损是年轻患者股骨翻修置换术中一个具有挑战性的问题。我们评估了使用冻干同种异体骨假体复合物(APC)进行股骨翻修置换术的效果。

方法

这是一项对16例患者(12例男性和4例女性)的回顾性研究,这些患者均有单侧股骨近端缺损(帕罗茨基III B型,13例;IV型,3例),采用冻干APC进行翻修。平均7年的随访包括使用梅里尔·达布尼评分和X线片进行评估。

结果

随访时,髋关节的平均疼痛、功能和活动范围评分均有所改善。5年移植物存活率为87%,估计中位生存期为8.8年。3例患者无需支撑即可行走,10例患者使用拐杖可无限制行走,2例患者使用双拐行走,1例患者使用助行器行走。X线片显示3个股骨(19%)的移植物与宿主交界处未愈合,但只有1例患者有症状。4个股骨(25%)观察到无症状的转子不愈合。术后9年有2例患者出现中度移植物吸收,1例移植物在7年时出现轻度吸收。2例患者出现小于2 cm的下沉,1例患者出现3.5 cm的下沉。

结论

本研究表明,在年轻患者中使用冻干APC治疗严重股骨缺损可取得可接受的结果。冻干APC可能对股骨翻修置换术有用。

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