水仙变种（中国水仙）的化学成分及其抗氧化活性。
Chemical constituents of Narcissus tazetta var. chinensis and their antioxidant activities.
作者信息
Fu Ka-Li, Li Xian, Ye Ji, Lu Lu, Xu Xi-Ke, Li Hui-Liang, Zhang Wei-Dong, Shen Yun-Heng
机构信息
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology of Natural Products, Kunming Medical University, Kunming 650500, Yunnan, China.
出版信息
Fitoterapia. 2016 Sep;113:110-6. doi: 10.1016/j.fitote.2016.07.013. Epub 2016 Jul 28.
Two new flavan derivatives tazettones C-D (1-2), one new β-coumaranone (tazettone E, 3), one new flavan (tazettone F, 4), and one new phenylpropanoid (tazettone G, 5), together with six known flavonoids (6-11), were isolated from the bulbs of Narcissus tazetta var. chinensis Roem. Their structures were elucidated by spectroscopic analysis. In addition, the structures of 1-3 were confirmed by single crystal X-ray diffraction. All isolated compounds were tested for antioxidant activity by Cell Counting Kit-8 (CCK-8) assay. Compounds 6-8 and 10-11 exhibited potent antioxidant activity against H2O2-induced impairment in human SH-SY5Y neuroblastoma cells at tested concentrations.
从水仙变种中国水仙的鳞茎中分离出两种新的黄烷衍生物塔泽酮C-D（1-2）、一种新的β-香豆满酮（塔泽酮E，3）、一种新的黄烷（塔泽酮F，4）和一种新的苯丙素（塔泽酮G，5），以及六种已知的黄酮类化合物（6-11）。通过光谱分析阐明了它们的结构。此外，通过单晶X射线衍射确定了1-3的结构。所有分离得到的化合物均通过细胞计数试剂盒-8（CCK-8）法检测其抗氧化活性。在测试浓度下，化合物6-8和10-11对H2O2诱导的人SH-SY5Y神经母细胞瘤细胞损伤表现出较强的抗氧化活性。
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