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有症状的转移性脊髓压迫症的后路手术方法

Posterior approaches for symptomatic metastatic spinal cord compression.

作者信息

Molina Camilo, Goodwin C Rory, Abu-Bonsrah Nancy, Elder Benjamin D, De la Garza Ramos Rafael, Sciubba Daniel M

机构信息

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

出版信息

Neurosurg Focus. 2016 Aug;41(2):E11. doi: 10.3171/2016.5.FOCUS16129.

Abstract

Surgical interventions for spinal metastasis are commonly performed for mechanical stabilization, pain relief, preservation of neurological function, and local tumor reduction. Although multiple surgical approaches can be used for the treatment of metastatic spinal lesions, posterior approaches are commonly performed. In this study, the role of posterior surgical procedures in the treatment of spinal metastases was reviewed, including posterior laminectomy with and without instrumentation for stabilization, transpedicular corpectomy, and costotransversectomy. A review of the literature from 1980 to 2015 was performed using Medline, as was a review of the bibliographies of articles meeting preset inclusion criteria, to identify studies on the role of these posterior approaches among adults with spinal metastasis. Thirty-four articles were ultimately analyzed, including 1 randomized controlled trial, 6 prospective cohort studies, and 27 retrospective case reports and/or series. Some of the reviewed articles had Level II evidence indicating that laminectomy with stabilization can be recommended for improvement in neurological outcome and reduction of pain in selected patients. However, the use of laminectomy alone should be carefully considered. Additionally, transpedicular corpectomy and costotransversectomy can be recommended with the expectation of improving neurological outcomes and reducing pain in properly selected patients with spinal metastases. With improvements in the treatment paradigms for patients with spinal metastasis, as well as survival, surgical therapy will continue to play an important role in the management of spinal metastasis. While this review presents a window into determining the utility of posterior approaches, future prospective studies will provide essential data to better define the roles of the various options now available to surgeons in treating spinal metastases.

摘要

脊柱转移瘤的外科干预通常用于实现机械稳定、缓解疼痛、保留神经功能以及局部肿瘤缩减。尽管多种手术入路可用于治疗转移性脊柱病变,但后路手术是常用的方法。在本研究中,回顾了后路手术在脊柱转移瘤治疗中的作用,包括有或无内固定稳定的后路椎板切除术、经椎弓根椎体切除术和肋骨横突切除术。使用Medline对1980年至2015年的文献进行了回顾,并对符合预设纳入标准的文章的参考文献进行了回顾,以确定关于这些后路手术在成年脊柱转移瘤患者中的作用的研究。最终分析了34篇文章,包括1项随机对照试验、6项前瞻性队列研究以及27项回顾性病例报告和/或系列研究。一些被回顾的文章有II级证据表明,对于特定患者,可推荐行椎板切除加稳定术以改善神经功能和减轻疼痛。然而,单独使用椎板切除术应谨慎考虑。此外,对于适当选择的脊柱转移瘤患者,推荐行经椎弓根椎体切除术和肋骨横突切除术,以期改善神经功能和减轻疼痛。随着脊柱转移瘤患者治疗模式以及生存率的提高,手术治疗将继续在脊柱转移瘤的管理中发挥重要作用。虽然本综述为确定后路手术的效用提供了一个窗口,但未来的前瞻性研究将提供重要数据,以更好地界定目前外科医生在治疗脊柱转移瘤时可用的各种选择的作用。

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