Adıgüzel Emre, Yüksel Emine, Safaz İsmail, Kenan Tan Arif
Emre Adıgüzel, MD, TSK Rehabilitasyon Merkezi, 06530 Bilkent Ankara, Turkey;
Acta Dermatovenerol Croat. 2016 Jun;24(2):137-9.
Mal de Meleda is a rare autosomal recessive skin disease which is known as keratoderma palmoplantaris transgradiens. Here we report a case of Mal de Meleda who had skin lesions in the residual limb and pseudoainhum in the thigh after traumatic lower leg amputation. A 71-year-old female was admitted to our tertiary hospital for prosthetic rehabilitation. On the physical examination, thickening of the skin on palms, left sole and residual limb was present. The patient reported that she had these skin lesions since infancy and she realized new skin lesions after amputation in the residual limb. We requested dermatology consultation and she was diagnosed as Mal de Meleda. To our knowledge, this is the first Mal de Meleda case in the literature with new lesions at the residual limb. Although exact pathophysiological mechanisms are not well known in Mal de Meleda, prosthesis use might have accelerated disease process in our patient.
梅勒达病是一种罕见的常染色体隐性皮肤病，被称为进行性掌跖角化病。在此，我们报告一例梅勒达病患者，其在小腿外伤性截肢后残肢出现皮肤病变，大腿出现假并指。一名71岁女性因假肢康复入住我们的三级医院。体格检查发现手掌、左脚底和残肢皮肤增厚。患者报告自婴儿期就有这些皮肤病变，截肢后残肢出现了新的皮肤病变。我们请皮肤科会诊，她被诊断为梅勒达病。据我们所知，这是文献中首例残肢出现新病变的梅勒达病病例。尽管梅勒达病的确切病理生理机制尚不清楚，但使用假肢可能加速了我们这位患者的疾病进程。
