Jiang B, Klueber K M
Medical Sciences Program, Indiana University School of Medicine, Bloomington.
Muscle Nerve. 1989 Jan;12(1):67-77. doi: 10.1002/mus.880120113.
A previous histochemical and morphometric study demonstrated that castration caused a significant decrease in myofiber and muscle size in the extensor digitorum longus (EDL) muscles of male ReJ 129 mice. The objective of the present study was to examine the effects of castration on the morphology and physiology of the EDL. Muscle wet weight was significantly decreased in the castrated group. The morphological survey demonstrated a significant degree of degeneration in the EDL muscles from castrated animals, consisting of disruption of normal myofilament arrangement and necrosis, invasion of active macrophages, and atrophic myofibers. These findings were significantly correlated with the decrease in peak tension observed in the castrated groups. No significant difference was detected in the time to peak tension and half-relaxation time in the castrated groups compared with the control. Thus, alterations of the morphological integrity and myofiber size of skeletal muscle affect muscle strength in castrated animals.
先前的一项组织化学和形态测量学研究表明，去势导致雄性ReJ 129小鼠的趾长伸肌（EDL）中肌纤维和肌肉大小显著减小。本研究的目的是检查去势对EDL形态和生理的影响。去势组的肌肉湿重显著降低。形态学检查表明，去势动物的EDL肌肉出现明显程度的退化，包括正常肌丝排列紊乱和坏死、活跃巨噬细胞浸润以及肌纤维萎缩。这些发现与去势组中观察到的峰值张力降低显著相关。与对照组相比，去势组在达到峰值张力的时间和半松弛时间方面未检测到显著差异。因此，骨骼肌形态完整性和肌纤维大小的改变会影响去势动物的肌肉力量。
