Department of Biochemistry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
CREST, JST, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Nat Commun. 2016 Aug 1;7:12319. doi: 10.1038/ncomms12319.
Behavioural tagging is the transformation of a short-term memory, induced by a weak experience, into a long-term memory (LTM) due to the temporal association with a novel experience. The mechanism by which neuronal ensembles, each carrying a memory engram of one of the experiences, interact to achieve behavioural tagging is unknown. Here we show that retrieval of a LTM formed by behavioural tagging of a weak experience depends on the degree of overlap with the neuronal ensemble corresponding to a novel experience. The numbers of neurons activated by weak training in a novel object recognition (NOR) task and by a novel context exploration (NCE) task, denoted as overlapping neurons, increases in the hippocampal CA1 when behavioural tagging is successfully achieved. Optical silencing of an NCE-related ensemble suppresses NOR-LTM retrieval. Thus, a population of cells recruited by NOR is tagged and then preferentially incorporated into the memory trace for NCE to achieve behavioural tagging.
行为标记是指由于与新经验的时间关联，将由弱经验引起的短期记忆转化为长期记忆（LTM）。神经元集合相互作用以实现行为标记的机制尚不清楚。在这里，我们表明，依赖于与对应于新经验的神经元集合的重叠程度，检索由弱经验的行为标记形成的 LTM。在新颖物体识别（NOR）任务和新颖环境探索（NCE）任务中，弱训练激活的神经元数量（表示为重叠神经元）在海马 CA1 中增加，当行为标记成功实现时。与 NCE 相关的集合的光沉默抑制 NOR-LTM 检索。因此，通过 NOR 招募的细胞群体被标记，然后优先整合到用于 NCE 的记忆痕迹中，以实现行为标记。
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