Llibre Alba, Klenerman Paul, Willberg Christian B
Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.
Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford OX3 9DU, UK.
Immunol Lett. 2016 Sep;177:62-9. doi: 10.1016/j.imlet.2016.07.007. Epub 2016 Jul 28.
Lectins and C-type lectins are a heterogeneous group of proteins with a diverse range of functions. Two C-type lectins, found in the Natural Killer gene Complex (NKC), Lectin-like transcript 1 (LLT1) and CD161, have recently gained interest from a broad range of immunological and non-immunological fields. LLT1 in particular has a diverse functional repertoire, from NK cell and B cell regulation to bone metabolism. This review seeks to bring together nearly two decades of research on these receptors and describe their importance in the immune system.
凝集素和C型凝集素是一类功能多样的异质性蛋白质。在自然杀伤基因复合体（NKC）中发现的两种C型凝集素，即凝集素样转录物1（LLT1）和CD161，最近在广泛的免疫学和非免疫学领域引起了关注。特别是LLT1具有多种功能，从自然杀伤细胞和B细胞调节到骨代谢。这篇综述旨在汇集近二十年来对这些受体的研究，并描述它们在免疫系统中的重要性。
