Timmermans Sjoerd A M E G, Christiaans Maarten H L, Abdul-Hamid Myrurgia A, Stifft Frank, Damoiseaux Jan G M C, van Paassen Pieter
Department of Internal Medicine, Division of Nephrology and Clinical Immunology , Maastricht University Medical Centre, Maastricht.
Department of Pathology , Maastricht University Medical Centre , Maastricht , The Netherlands.
Clin Kidney J. 2016 Aug;9(4):556-9. doi: 10.1093/ckj/sfw041. Epub 2016 May 26.
Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in the interstitial infiltrate, indicating a cellular autoimmune response. After immunosuppressive treatment, renal function either improved or stabilized in both patients. In conclusion, granulomatous interstitial nephritis is a genuine extraintestinal manifestation of Crohn's disease, the treatment of which should include immunosuppressive agents.
在<1%的原发性肾活检中观察到肉芽肿性间质性肾炎。在此，我们描述了两名与克罗恩病相关的肉芽肿性间质性肾炎患者。循环辅助性T细胞和细胞毒性T细胞高度活化，且两种细胞类型在间质浸润中占主导地位，提示存在细胞性自身免疫反应。免疫抑制治疗后，两名患者的肾功能均得到改善或稳定。总之，肉芽肿性间质性肾炎是克罗恩病真正的肠外表现，其治疗应包括免疫抑制剂。
