变量对固体脂质纳米粒和纳米结构脂质载体粒径的影响；比较文献综述
The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review.
作者信息
Azhar Shekoufeh Bahari Leila, Hamishehkar Hamed
机构信息
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Adv Pharm Bull. 2016 Jun;6(2):143-51. doi: 10.15171/apb.2016.021. Epub 2016 Jun 30.
Abstract
During the past decade, pharmaceutical science has seen rapid growth in interest for nanoscale materials. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are popular research topics recently introduced as nano-scale drug carriers; they have shown numerous merits in drug delivery. Size is the most important index in a nanocarrier affecting its drug delivery efficiency. The influence of preparation conditions and type of lipidic components on the size of SLN and NLC in comparable states seems to be interesting for researchers who investigate these types of carriers. This review highlights the results of SLN and NLC particle size and size distribution comparisons.
摘要
在过去十年中，药物科学领域对纳米级材料的兴趣迅速增长。固体脂质纳米粒（SLNs）和纳米结构脂质载体（NLCs）是最近作为纳米级药物载体引入的热门研究课题；它们在药物递送方面已显示出众多优点。尺寸是影响纳米载体药物递送效率的最重要指标。制备条件和脂质成分类型对处于可比状态的SLN和NLC尺寸的影响，对于研究这类载体的研究人员来说似乎很有趣。本综述重点介绍了SLN和NLC粒径及粒径分布比较的结果。
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