Gottardello L, Galeazzi E, Pagano R, Cannizzaro R, Pasquali C, Battaglia G, Vianello F, Di Mario F, Naccarato R
Policlinico Universitario, Padova.
Minerva Med. 1989 Jun;80(6):541-7.
Conflicting data are present in the literature on pathophysiological role of serum gastrin and peptic ulcer disease. The aim of this study was to evaluate, in duodenal ulcer patients, the possible correlation between post-prandial serum gastrin concentrations and some epidemiological (sex, family history, onset of the disease, blood group status, smoking habit, alcohol consumption) and clinical (effectiveness of therapy, bleeding episodes) factors. The gastrin levels were expressed in absolute values and as per cent increase of fasting serum gastrin concentrations. As regards sex, the per cent increase of fasting serum gastrin concentration was significantly higher in females (No. 16) than in males (No. 60) at 30 and 60 minutes (192.25% vs 116.52% and 105.42% vs 40.96% respectively; p less than 0.05 and p less than 0.005). Post-prandial serum gastrin concentrations, expressed as per cent increase, were higher in heavy drinkers (No. 14) and statistically significant at 120 minutes (40.57% vs 9.58%, p less than 0.025); as well as in smoker patients (No. 31), at 15, 30 and 60 minutes (227.59% vs 123.52%, 177.23% vs 101.62%, 0.025 and p less than 0.05). Post-prandial gastrin was unrelated to blood group status, onset of the disease, family history, effectiveness of medical treatment and bleeding episodes.
关于血清胃泌素的病理生理作用和消化性溃疡疾病，文献中存在相互矛盾的数据。本研究的目的是评估十二指肠溃疡患者餐后血清胃泌素浓度与一些流行病学因素（性别、家族史、疾病发作、血型状况、吸烟习惯、饮酒情况）和临床因素（治疗效果、出血事件）之间可能存在的相关性。胃泌素水平以绝对值表示，并以空腹血清胃泌素浓度的百分比增加来表示。关于性别，在30分钟和60分钟时，女性（16例）空腹血清胃泌素浓度的百分比增加显著高于男性（60例）（分别为192.25%对116.52%和105.42%对40.96%；p<0.05和p<0.005）。以百分比增加表示的餐后血清胃泌素浓度，在重度饮酒者（14例）中较高，在120分钟时具有统计学意义（40.57%对9.58%，p<0.025）；在吸烟患者（31例）中，在15、30和60分钟时也较高（227.59%对123.52%、177.23%对101.62%，p<0.025和p<0.05）。餐后胃泌素与血型状况、疾病发作、家族史、药物治疗效果和出血事件无关。
