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5-羧酰胺色胺仅通过5-HT1A受体模拟5-羟色胺引起的海马锥体细胞超极化。

5-Carboxyamidotryptamine mimics only the 5-HT elicited hyperpolarization of hippocampal pyramidal cells via 5-HT1A receptor.

作者信息

Beck S G

机构信息

Department of Pharmacology, Mount Sinai School of Medicine of CUNY, NY 10029.

出版信息

Neurosci Lett. 1989 Apr 24;99(1-2):101-6. doi: 10.1016/0304-3940(89)90272-3.

DOI:10.1016/0304-3940(89)90272-3
PMID:2748003
Abstract

Perfusion of the rat hippocampal slice in vitro by 5-hydroxytryptamine (5-HT) elicits 3 distinct actions recorded intracellularly from pyramidal cells in area CA1: a hyperpolarization, reduction in spike train elicited afterhyperpolarization (AHP) and depolarization. 5-Carboxyaminotryptamine (5-CT) mimics the membrane hyperpolarization elicited by 5-HT through its action on the 5-HT1A receptor; however, 5-CT does not mimic 5-HT in reducing the amplitude of the AHP or the depolarization of membrane potential. The hyperpolarizing effect of 5-CT is blocked by spiperone. These data provide evidence that the inhibitory effect of 5-HT is mediated primarily by the 5-HT1A receptor.

摘要

用5-羟色胺（5-HT）对大鼠海马切片进行体外灌注，可从CA1区锥体细胞的细胞内记录到三种不同的作用：超极化、超极化后电位（AHP）引发的锋电位序列减少以及去极化。5-羧基氨基色胺（5-CT）通过作用于5-HT1A受体模拟5-HT引发的膜超极化；然而，5-CT在降低AHP幅度或膜电位去极化方面并不能模拟5-HT。5-CT的超极化作用被螺哌隆阻断。这些数据证明5-HT的抑制作用主要由5-HT1A受体介导。

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Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class.血清素对大鼠离体脊髓运动节律的抑制作用是由5-HT1受体类介导的。
Proc Biol Sci. 1998 Nov 7;265(1410):2073-80. doi: 10.1098/rspb.1998.0542.
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4-Aminopyridine and low Ca2+ differentiate presynaptic inhibition mediated by neuropeptide Y, baclofen and 2-chloroadenosine in rat hippocampal CA1 in vitro.
4-氨基吡啶和低钙可区分大鼠海马CA1区体外由神经肽Y、巴氯芬和2-氯腺苷介导的突触前抑制。
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