Rossen Jennifer, Amram Alec, Milani Behrad, Park Dongwook, Harthan Jennifer, Joslin Charlotte, McMahon Timothy, Djalilian Ali
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.
Illinois College of Optometry, Illinois Eye Institute, Chicago, IL, USA.
Ocul Surf. 2016 Oct;14(4):419-434. doi: 10.1016/j.jtos.2016.06.003. Epub 2016 Jul 30.
Limbal stem cell deficiency (LSCD) is a pathologic condition caused by the dysfunction and/or destruction of stem cell precursors of the corneal epithelium, typified clinically by corneal conjunctivalization. The purpose of this review is to critically discuss a less well-known cause of limbal stem cell disease: contact lens (CL) wear. A literature search was conducted to include original articles containing patients with CL-induced LSCD. This review describes epidemiology, diagnostic strategies, pathogenesis, differential diagnosis, and treatment modalities for this condition.
角膜缘干细胞缺乏症（LSCD）是一种由角膜上皮干细胞前体功能障碍和/或破坏引起的病理状况，临床上以角膜结膜化作为典型表现。本综述的目的是批判性地讨论角膜缘干细胞疾病一个不太为人所知的病因：隐形眼镜（CL）佩戴。进行了文献检索，纳入了包含隐形眼镜导致的LSCD患者的原始文章。本综述描述了这种疾病的流行病学、诊断策略、发病机制、鉴别诊断和治疗方式。
